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Principal Investigator  
Principal Investigator's Name: Christos Davatzikos
Institution: University of Pennsylvania
Department: Radiology
Country: United States of America
Proposed Analysis: High-dimensional classification of MRI in MCI patients, in order to construct classifiers that have predictive value in terms of conversion from MCI to AD
Additional Investigators  
Investigator's Name: Adam Spira
Proposed Analysis: Correlation between MRI volumetric brain change and disordered sleep.
Investigator's Name: Brendan Lucey
Proposed Analysis: Correlation between MRI volumetric brain change and sleep disorder.
Investigator's Name: Jill Rabinowitz
Proposed Analysis: Correlation between MRI volumetric brain change and sleep disorders.
Investigator's Name: Yuhan Cui
Proposed Analysis: NIAGADS genetics and MRI analysis
Investigator's Name: Elizabeth Mamourian
Proposed Analysis: High-dimensional classification of MRI in MCI patients, in order to construct classifiers that have predictive values in terms of conversion from MCI to AD. Specifically, combining MRI biomarker (SPARE-AD, SPARE-MCI), CSF biomarkers (Tau, Abeta and Ptau), Cognitive Score (MMSE and ADAS-cog) and Genetic Info (APOE4 and etc) to evaluate individual and joint prediction for MCI to AD progression. Longitudinal model for analysis of structural MRI data.