There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Aimee Karstens |
| Institution: | University of Illinois, Chicago; Mayo Clinic, Rochester |
| Department: | Anatomy and Cell Biology; Psychology |
| Country: | |
| Proposed Analysis: | APOE frequency distributions and the relative risk for AD are based off of homogenous White populations. African Americans make up a genetically heterogeneous population. Numerous cohort studies suggest that there is a greater proportion of both risk (e4) and protective (e2) APOE alleles in African Americans. In turn, the contribution of APOE, the APOE gene cluster, and the interplay with modifiable factors to AD risk warrants further investigation in populations with African lineage. As African Americans are disproportionately impacted by AD, this is necessary for developing methods of prevention and treatment targeting APOE and modifiable risk factors. For this systematic review and meta-analysis, we aim to establish APOE genotype frequencies in African American, Afro-Caribbean, African, and other African descendant populations. We will further determine APOE genotype relative risk for AD and cognitive decline in African American populations. The use of numerous cohorts will allow us to further address potential demographic moderators relevant to regional differences that historically could have both genetic and environmental implications (e.g., admixed populations, education). |
| Additional Investigators | |
| Investigator's Name: | Mary Jo LaDu |
| Proposed Analysis: | APOE frequency distributions and the relative risk for AD are based off of homogenous White populations. African Americans make up a genetically heterogeneous population. Numerous cohort studies suggest that there is a greater proportion of both risk (e4) and protective (e2) APOE alleles in African Americans. In turn, the contribution of APOE, the APOE gene cluster, and the interplay with modifiable factors to AD risk warrants further investigation in populations with African lineage. As African Americans are disproportionately impacted by AD, this is necessary for developing methods of prevention and treatment targeting APOE and modifiable risk factors. For this systematic review and meta-analysis, we aim to establish APOE genotype frequencies in African American, Afro-Caribbean, African, and other African descendant populations. We will further determine APOE genotype relative risk for AD and cognitive decline in African American populations. The use of numerous cohorts will allow us to further address potential demographic moderators relevant to regional differences that historically could have both genetic and environmental implications (e.g., admixed populations, education). |
