• Select the area you would like to search.
  • ACTIVE INVESTIGATIONS Search for current projects using the investigator's name, institution, or keywords.
  • EXPERTS KNOWLEDGE BASE Enter keywords to search a list of questions and answers received and processed by the ADNI team.
  • ADNI PDFS Search any ADNI publication pdf by author, keyword, or PMID. Use an asterisk only to view all pdfs.
Principal Investigator  
Principal Investigator's Name: George Blanck
Department: Molecular Medicine
Proposed Analysis: We would like to access the exome files for Alzheimer’s Disease (AD) studies to better ascertain the impact of certain immune receptor (IR) recombinations on the progression of Alzheimer’s patients. Access to these files also requires ADNI approval. First, we will mine the exomes for all IR recombinations present in the AD exome files using our previously published algorithms and software [4-6, 9]. These studies have been successful in identifying IR recombination reads that were strongly associated with distinct survival rates in various cancers. In particular, we have been able to utilize a similar methodology to identify specific T-Cell recombinations associated with cancer features by using the recombinations that are obtained from blood sample exomes. For example, recently published papers from our group have revealed consistent features of T-cell receptor recombinations, obtained from cancer patient blood samples, which were associated with features of cancer progression [4, 8]. Therefore, we hypothesize that we can detect specific IR recombination features from blood-resident T- or B-cells that are relevant to AD clinical features. Thus, we will first identify IR recombinations found within the AD, blood exomes; and then match features of these IRs, such as the chemical aspects of the IR antigen binding sites [1, 4, 5] with clinical characteristics, e.g., age of onset, diagnostic status, and cognitive measures. We thus expect to identify certain IR recombinations associated with distinct prognoses. It should also be noted that there have been previous studies linking HLA-DR alleles to late-onset AD [10]. This is of particular interest, because of our previous work linking T-cell receptor, V or J usage, HLA allele combinations to distinct cancer survival rates [2, 3, 7, 8]. Thus, we will also programmatically obtain the HLA alleles from the exome files and determine whether any T-cell receptor, V or J usage, HLA allele combinations are associated with particular features of AD development.
Additional Investigators  
Investigator's Name: Taha Huda
Proposed Analysis: Medical student listed on "Terms of access agreement for data" signed by USF and UPenn. This student will be participating in the approved projects for ADSP and ADNI. Analyses involves assessment of adaptive immune receptor recombinations associated with Alzheimer's disease.
Investigator's Name: Mallika Varkhedi
Proposed Analysis: Ms. Varkhedi is a medical student in my research group at the USF Morsani College of Medicine. Ms. Varkhedi has been added to the DUA and has been approved by UPenn for ADSP access. Her status will be identical to the status of Mr. Huda, previously added as a co-investigator to my account. Thank you.