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Principal Investigator  
Principal Investigator's Name: Busra Gok
Institution: Boston University
Department: Biology
Country:
Proposed Analysis: Specific Aim: To identify molecular markers for Alzheimer’s Disease (AD) by performing massively parallel single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from AD patients, Asymptomatic AD (AsymAD) patients and healthy controls. Our goal is to find new molecular markers and novel therapeutic targets in the peripheral blood immune system of Alzheimer’s Disease patients and find early markers by profiling AsymAD patient PBMCs. We will utilize a cutting edge technology, massively-parallel single cell RNA-seq, where thousands of single cells are simultaneously analyzed in emulsion droplets. We will obtain single cell resolution mRNA expression profiles for each of the immune cell subtypes in the peripheral blood samples from AD patients and matching controls. Bioinformatic analysis will be performed to identify novel molecular markers and potential therapeutic targets in AD.
Additional Investigators  
Investigator's Name: Christine Cheng
Proposed Analysis: Specific Aim: To identify molecular markers for Alzheimer’s Disease (AD) by performing massively parallel single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from AD patients, Asymptomatic AD (AsymAD) patients and healthy controls. Our goal is to find new molecular markers and novel therapeutic targets in the peripheral blood immune system of Alzheimer’s Disease patients and find early markers by profiling AsymAD patient PBMCs. We will utilize a cutting edge technology, massively-parallel single cell RNA-seq, where thousands of single cells are simultaneously analyzed in emulsion droplets. We will obtain single cell resolution mRNA expression profiles for each of the immune cell subtypes in the peripheral blood samples from AD patients and matching controls. Bioinformatic analysis will be performed to identify novel molecular markers and potential therapeutic targets in AD.