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Principal Investigator  
Principal Investigator's Name: Adam Brickman
Institution: College of Physicians and Surgeons, Columbia University
Department: Taub Institute
Proposed Analysis: We propose to examine whether areas that appear as increased lucency (hyperintense) on T2-weighted FLAIR images are PIB "positive," and, if so, determine whether this varies as a function of location of WMH or as a function of diagnosis (normal, MCI, AD).
Additional Investigators  
Investigator's Name: Frank Provenzano
Proposed Analysis: relationship among PIB, WMH, and cognitive outcomes
Investigator's Name: Giuseppe Tosto
Proposed Analysis: relationship of WMH with cognitive and functional decline. Relationship of CSF markers of alpha synuclein with AD biomarkers and clinical symptoms.