There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Ben Life |
| Institution: | University of British Columbia |
| Department: | Medical Genetics |
| Country: | |
| Proposed Analysis: | I am studying a gene that, when mutated, is known to cause dementia. Variation in a regulatory site in the 3' untranslated region is associated with reduced expression of this gene and increased risk of developing Alzheimer's disease. I hypothesize that non-coding variants that reduce expression of this gene are also associated with an increased risk of developing Alzheimer's disease. Using bioinformatic methods, I have predicted the locations of regulatory regions in which variation is likely to alter expression of our gene of interest. I would like to access your Alzheimer's disease patient whole genome sequence database to determine if variants in these regulatory regions are enriched in Alzheimer's patients. |
| Additional Investigators |
