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Principal Investigator  
Principal Investigator's Name: August Smit
Institution: Vrije Universiteit Amsterdam
Department: Neurosciences
Proposed Analysis: I will be comparing the ADNI data with a brain tissue proteomics dataset that I acquired of AD cases and controls (~200 brain samples). Also I will be using a new statistical method for proteomics analysis and use the ADNI set to see which proteins may indeed be present in CSF.
Additional Investigators  
Investigator's Name: Frank Koopmans
Proposed Analysis: 1. Comparison of ADNI data with in house acquired AD/control proteomics data (~200 samples). 2. Benchmarking a newly developed method in order to see whether it improves the detection of CSF proteins (ADNI is reference set).