There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Andrew Jahn |
| Institution: | University of Michigan |
| Department: | fMRI Laboratory |
| Country: | |
| Proposed Analysis: | We propose to analyze the resting-state, structural, and diffusion data from one of the ADNI sites (preferably OSU) in order to obtain pilot data for an R01 grant submission. We are interested in how subjective ratings of pain correlate with differences in grey and white matter, through analysis of volume and thickness in FreeSurfer and streamlines in MRtrix. We would also like to include ASL data, if available, to create a comprehensive picture of which regions of the brain are modulated by subjective pain within this population. |
| Additional Investigators | |
| Investigator's Name: | Todd Monroe |
| Proposed Analysis: | We propose using structural, flair, ASL, DTI, and resting state data to examine the central pain processing networks in people with AD, MCI, relative to controls. We will first plan a feasibility cross sectional (most likely but they do have longitudinal data which can complicate the analyses) pilot study with limited ADNI data and if successful propose a larger R01 level application. |
| Investigator's Name: | Michelle Failla |
| Proposed Analysis: | We propose using structural, flair, ASL, DTI, and resting state data to examine the central pain processing networks in people with AD, MCI, relative to controls. We will first plan a feasibility cross sectional (most likely but they do have longitudinal data which can complicate the analyses) pilot study with limited ADNI data and if successful propose a larger R01 level application. |
| Investigator's Name: | Ron Cown |
| Proposed Analysis: | We propose using structural, flair, ASL, DTI, and resting state data to examine the central pain processing networks in people with AD, MCI, relative to controls. We will first plan a feasibility cross sectional (most likely but they do have longitudinal data which can complicate the analyses) pilot study with limited ADNI data and if successful propose a larger R01 level application. UPDATED (2021-02-18) :Our lab examines the functional and structural basis of pain circuitry in aging and dementia. We propose using structural MRI, FLAIR, ASL, DTI, and resting state data to examine the central pain processing networks in people with Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI), relative to controls. We intend to use cross sectional and longitudinal data, where available, to examine pain networks. Information derived from these analyses will then be used to design prospective studies examining functional and structural brain alterations in AD and MCI in relation to experimental pain processing. These studies will provide critical novel information regarding pain processing in AD and MCI and will form the basis for designing assessments and interventions to treat pain. |
| Investigator's Name: | Alison Anderson |
| Proposed Analysis: | We propose using structural, flair, ASL, DTI, and resting state data to examine the central pain processing networks in people with AD, MCI, relative to controls. We will first plan a feasibility cross sectional (most likely but they do have longitudinal data which can complicate the analyses) pilot study with limited ADNI data and if successful propose a larger R01 level application. UPDATED (2021-02-18) :Our lab examines the functional and structural basis of pain circuitry in aging and dementia. We propose using structural MRI, FLAIR, ASL, DTI, and resting state data to examine the central pain processing networks in people with Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI), relative to controls. We intend to use cross sectional and longitudinal data, where available, to examine pain networks. Information derived from these analyses will then be used to design prospective studies examining functional and structural brain alterations in AD and MCI in relation to experimental pain processing. These studies will provide critical novel information regarding pain processing in AD and MCI and will form the basis for designing assessments and interventions to treat pain. |
