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Principal Investigator  
Principal Investigator's Name: Tayla Clasper
Institution: University of Auckland
Department: Department of Medical and Health Sciences
Proposed Analysis: Alzheimer's disease (AD) is the dominant neuropathology in dementia and accounts for 60 to 80 percent of dementia cases. Brain magnetic resonance imaging (MRI) has played a variety of important roles in the study of AD over the past decades. The purpose of this project is going to investigate the correlation of lifestyle factors of AD patients with the corresponding brain MRI changes such as brain volume, cortical thickness, or structural and functional connectivity, etc. T1-weighted MRI brain scans will be used to calculate the volumetric measurements such as, brain volumes, grey matter and white matter volumes, subcortical volumes, cortical thickness, cortical surface area, etc. The functional MRI and diffusion tensor MRI can be used to calculate the advanced measurements such as brain connectivity, fractional anisotropy (FA), apparent diffusion coefficient (ADC), for a-priori determined regions of interests. Statistical analysis will then be applied to reveal the relationship of the quantitative MRI measurements with the lifestyle factors.
Additional Investigators