×
  • Select the area you would like to search.
  • ACTIVE INVESTIGATIONS Search for current projects using the investigator's name, institution, or keywords.
  • EXPERTS KNOWLEDGE BASE Enter keywords to search a list of questions and answers received and processed by the ADNI team.
  • ADNI PDFS Search any ADNI publication pdf by author, keyword, or PMID. Use an asterisk only to view all pdfs.
Principal Investigator  
Principal Investigator's Name: Bernardo Villa-Sanchez
Institution: University of Trento
Department: Center for Mind/Brain Sciences
Country:
Proposed Analysis: Our aim is to investigate whether the increase of blood pressure across the lifespan in healthy individuals correlates with a decrease in cognitive performances. In particular, we aim to evaluate how such relationship varies across subclinical groups, identified according to the 2018 ESC/ESH guideline (optimal, normal, high normal blood pressure). First, we will characterize the subclinical groups, in terms of their demographic characteristic, using descriptive statistics (e.g., mean, standard deviation (SD), etc.). Differences between groups will be assessed using either parametric or non-parametric approaches, depending on the underlying data distributions (e.g., analysis of variance or Kruskal-Wallis tests for continuous variables and chi-squared or Fisher’s exact test for categorical variables). Second, we will carry out an explorative analysis to assess the relationship between age-related changes in cognitive performance and increase of blood pressure indexes in each identified group (optimal, normal, high normal). To do so, we propose the use of linear mixed model to assess the impact of blood pressure and other indexes derived from blood pressure (e.g. mean arterial pressure) on cognitive performance over time (dependent variable), while taking inter-subject variability into account. The variables age, sex, education, antihypertensive medication, alcohol consumption, smoking, physical activity or other variables related with cardiovascular health will be considered as potential covariates.
Additional Investigators  
Investigator's Name: Sara Assecondi
Proposed Analysis: Our aim is to investigate whether the increase of blood pressure across the lifespan in healthy individuals correlates with a decrease in cognitive performances. In particular, we aim to evaluate how such relationship varies across subclinical groups, identified according to the 2018 ESC/ESH guideline (optimal, normal, high normal blood pressure). First, we will characterize the subclinical groups, in terms of their demographic characteristic, using descriptive statistics (e.g., mean, standard deviation (SD), etc.). Differences between groups will be assessed using either parametric or non-parametric approaches, depending on the underlying data distributions (e.g., analysis of variance or Kruskal-Wallis tests for continuous variables and chi-squared or Fisher’s exact test for categorical variables). Second, we will carry out an explorative analysis to assess the relationship between age-related changes in cognitive performance and increase of blood pressure indexes in each identified group (optimal, normal, high normal). To do so, we propose the use of linear mixed model to assess the impact of blood pressure and other indexes derived from blood pressure (e.g. mean arterial pressure) on cognitive performance over time (dependent variable), while taking inter-subject variability into account. The variables age, sex, education, antihypertensive medication, alcohol consumption, smoking, physical activity or other variables related with cardiovascular health will be considered as potential covariates.