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Principal Investigator  
Principal Investigator's Name: Snigdha Agarwal
Institution: Heritage Institute of Technology
Department: Information Technology
Proposed Analysis: The purpose of this study is to explore the connection changes in brain networks in the process from NC to AD, and uncovers the underlying connection mechanism that shapes the topologies of AD brain networks. In particular, we propose a mutual information brain network model (MINM) from the perspective of graph theory to achieve our aim. MINM concerns the question of estimating the connection probability between two cortical regions with the consideration of both the mutual information of their observed network topologies and their Euclidean distance in anatomical space. In addition, MINM considers establishing and deleting connections, simultaneously, during the network modelling from the stage of NC to AD. Experiments show that MINM is sufficient to capture an impressive range of topological properties of real brain networks such as characteristic path length, network efficiency, and transitivity, and it also provides an excellent fit to the real brain networks in degree distribution compared to experiential models. Thus, we anticipate that MINM may explain the connection mechanism for the formation of the brain network organization in AD patients.
Additional Investigators