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Principal Investigator  
Principal Investigator's Name: Abby Brand
Institution: Washington University School of Medicine
Department: Neurology - Bateman Lab
Proposed Analysis: We would like to request all the plasma Aβ data from FNIH plasma Aβ assay validation Study 1 datasets that were uploaded to LONI recently (in May) and all the related demographics, cognitive/clinical, biomarker, imaging biomarker data. The FNIH plasma Aβ assay validation Study 1 included plasma Aβ measured by six centers, WashU is one of the centers. The following analysis will be performed: 1. AUCs of plasma Aβ42/Aβ40 itself and with other biological variable (e.g. age, APOE, sex) in classifying amyloid PET status. 2. Correlations in plasma Aβ42, Aβ40, Aβ42/Aβ40 measured by all assays, and if low correlation, figure out the possible cause. Correlations between Aβ42/Aβ40 and other clinical/cognitive outcomes, biomarkers 3. Evaluate the percentage agreement and disagreement in the plasma Aβ42/Aβ40 status (positive, negative). Assess whether there is a pattern to miss categorization by type of assay (mass spec vs immunoassay), type of participants (cognitive status, age, APOE ε4 status, other biomarker, imaging biomarker status, etc.) 4. Compare the %CV of each assay and exam whether the %CV or the difference in ratio is the major factor that influence the performance of the assay in terms of classifying amyloid PET status.
Additional Investigators