There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Andrew Jaffe |
| Institution: | RBNC Therapeutics |
| Department: | Data Science |
| Country: | |
| Proposed Analysis: | Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder with emerging genetic and molecular evidence in its etiology. Recent classes of methods have been developed to “impute” gene expression levels in hard-to-ascertain tissues like brain using just DNA sequence variation, for example prediXcan [PMID: 26258848] and TWAS [PMID: 26854917]. Importantly, these approaches impute expression levels within individual subjects using only common genetic variation from whole genome sequencing (WGS) or DNA microarrays, permitting disease-relevant downstream associations in richly-phenotyped clinical populations. While these algorithms have already published and publicly disseminated genotype/SNP “weights” to predict gene expression levels across all tissues in the Genotype By Tissue Expression (GTEx) project [PMID: 32913098], there have been few applications to AD. We therefore propose to apply existing GTEx – as well as our own custom - prediXcan weights from 11 different brain regions to genome-wide genotype data from ADNI and associate imputed expression levels with clinical traits related to symptom onset, severity, progression, and biomarker levels. We will also combine region-specific imputed expression levels in ADNI with parcellated neuroimaging data to add biological relevance and putative mechanisms for expression-trait associations as a form of multimodal analysis. These analyses together will identify novel genetic risk factors of AD and could inform new biomarkers and drug targets. |
| Additional Investigators | |
| Investigator's Name: | Chris Wilks |
| Proposed Analysis: | Responsible for genomic data processing and analysis |
| Investigator's Name: | Joshua Burt |
| Proposed Analysis: | Responsible for neuroimaging data processing and analysis |
| Investigator's Name: | Tathagata Banerjee |
| Proposed Analysis: | Responsible for integrative multimodal analyses of genomic and neuroimaging data |
| Investigator's Name: | Oscar Rodriguez |
| Proposed Analysis: | Same as main proposal |
| Investigator's Name: | Oscar Rodriguez |
| Proposed Analysis: | Same as main proposal |
| Investigator's Name: | Nathan Posener |
| Proposed Analysis: | Same as primary |
| Investigator's Name: | Sathish Koduru |
| Proposed Analysis: | Same as full proposal |
| Investigator's Name: | Ayman Zeine |
| Proposed Analysis: | Same as full proposal |
| Investigator's Name: | Emily Burke |
| Proposed Analysis: | Same as main analysis |
