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Principal Investigator  
Principal Investigator's Name: ZERAII Abderrazek
Institution: LRBTM-Tunis ElManar University
Department: Medical Technologies
Proposed Analysis: Alzheimer's disease (AD) is characterized by neurofibrillary tangles this feature occur in somewhat topographically distinct distributions in the brain.The outcome of AD is neuronal loss though exactly how histopathological features interact with each other and how they relate. It seems reasonable to identify that neuronal loss is the major critical to the development of cognitive impairment. Diffusion tensor imaging or DTI, an imaging technique capable of probing white matter tissue microstructure has recently confirmed degeneration of the white matter connections of the limbic-diencephalic network in AD. We will discuss in detail the aspect of DTI in terms of image acquisition and analysis as factors for reliable observation that are inform the understanding of this neurodegenerative diseases.
Additional Investigators