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Principal Investigator  
Principal Investigator's Name: Carlos Eduardo Muñoz Neira
Institution: University of Sheffield
Department: Department of Neuroscience
Proposed Analysis: Clinical insight understood as the capacity to properly identify a diagnosis and/or its symptoms is commonly impaired in different types of dementia. Making use of the ADNI database, the main objective of this analysis is to examine how several modalities of insight may vary across cognitively healthy controls (HC), and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Discrepancy scores will be estimated between the outcomes of the self-administered and informant-based versions of the Measurement of Everyday Cognition (ECog) in order to obtain measures of insight for the cohort (i.e. the higher the discrepancy score, the higher the impairment in insight -and vice versa-). Insight into memory, language, visuospatial and perceptual abilities, and executive functioning will be calculated according to the sub-scales offered by the ECog to carry out this analysis. Additionally, associations among such measures and other neuropsychological, behavioural and clinical variables will be also explored to characterise how insight may be shaped by them in distinct diagnostic groups. Lastly, an effort to investigate the neural underpinnings of different forms of insight will be conducted by covarying their corresponding measures with grey matter densities taken from the Magnetic Resonance Imaging (MRI) brain scans performed in the participants of this study. Other relevant scientific problems associated with impaired insight in MCI and AD might also be investigated, which will be correspondingly informed where appropriate.
Additional Investigators  
Investigator's Name: Jacob Wilkins
Proposed Analysis: Investigate whether levels of insight assessed at baseline across cognitively healthy controls, and patients with mild cognitive impairment and Alzheimer's disease may predict brain changes in subsequent stages/follow-ups.
Investigator's Name: Li Su
Proposed Analysis: Supervise analyses on potential neural correlates of impaired insight and how impaired insight may predict subsequent brain changes in cognitively healthy controls, and patients with mild cognitive impairment and Alzheimer's disease.