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Principal Investigator  
Principal Investigator's Name: Charley Budgeon
Institution: University Of Western Australia
Department: School of Mathematics and Statistics
Proposed Analysis: Alzheimer’s disease, the leading cause of dementia, currently costs 1% of GDP globally1. With the incidence of this disease predicted to increase at least three fold by 2050 we are faced with the unprecedented challenge of understanding, managing and curing this disease. This study aims to determine a set of axes that are dynamically associated with Alzheimer’s disease progression. Properties from known disease-specific biomarkers such as β-amyloid and tau in cerebrospinal fluid, structural, metabolic and neurochemical alterations in the brain measured through MRI and PET scanning, as well as clinical, neuropsychological and cognitive assessments were analysed in combination with more general measures of lifestyle and emotional wellbeing. The dynamic properties of these axes will be assessed to provide a quantitative understanding of the pathological features of this disease, including time to event information. This has the potential to provide imperative information for a wide range of applications including the design and timing of therapeutic interventions and planning for events such as residential care needs. The analyses aim to represent a multimodality approach to longitudinal analyses of a disease spectrum. Dimensionality reduction techniques will be incorporated to distil the information to a user-friendly format to encourage widespread adoption. Through these analyses a quantitative understanding of the order and interaction of relevant aspects of a disease process will be gained, in turn providing time to event estimations useful for furthering the knowledge of a disease course.
Additional Investigators