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Principal Investigator  
Principal Investigator's Name: Philip Barber
Institution: University of Calgary
Department: Clinical Neurosciences
Proposed Analysis: I am a neurologist with an academic interest in stroke and dementia. The purpose of this request is to compare rates of brain atrophy in our stroke and TIA patients to known neurodegenerative disorders and healthy controls, and explore potential modifiers of cerebral atrophy. Objectives We propose to compare rates of whole and hippocampal brain atrophy in non-demented patients with minor stroke and transient ischemic attack (TIA) to aged matched ADNI groups including Alzheimer’s Disease, Mild Cognitive Impairment, and healthy controls. Methods Brain atrophy rates will be measured from serial T1 MR imaging using FSL SIENA and FIRST software for whole brain and hippocampal volume. A linear regression will be adopted to model the association between cerebral atrophy rates and group (TIA versus ADNI groups), after adjusting for baseline demographic characteristics and other relevant clinical variables. Candidate predictors of cerebral brain atrophy will be: a) age, b) gender, c) educational level, d) MMSE score, e) neuropsychological test scores (with predictive utility of individual tests as well as domains to be explored), f) CSF ratio of phosphorylated tau to Aβ (dichotomized into AD versus non-AD pattern) Output We will obtain rates of cerebral atrophy in our minor stroke and TIA patients that will be compared with ADNI patient groups.
Additional Investigators