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RARC-Approved Studies

Table.  ADNI Biofluid Samples Sent to Investigators for RARC-Approved Studies
Shipment

Date

Principal Investigator Project Specimen Type Specimen Number Data Upload to ADNI/LONI
July 2018 Robert Nagele, UMDNJ

(Autoantibody Array)

Autoantibodies for AD detection Serum 406 ADNI1/GO/2 Baseline + Longitudinal Samples, 10 replicates Anticipated Completion Date: 3rd Q 2018
March 2018  William Hu, Emory University Center for Neurodegenerative Diseases CSF Cytokines/Chemokines

IA

CSF 400 ADNI 1,GO, 2 CSF Longitudinal Samples, 20 replicates Anticipated Completion Date: 4th Q 2018
January 2018 FNIH BC/Caprion Proteome Inc., Washington DC/Montreal, Quebec, Canada CMGA, NPTX2, VGF, CG2, FABP

mrm/mass spectrometry

CSF 730 ADNI1, GO, 2 CSF Longitudinal Samples, 20 replicates Anticipated Completion Date: 1st Q 2019
November 2017 Randall Bateman, Washington University School of Medicine Ab42/Ab40 in plasma of FBP+ / FBP-

mrm/mass spectrometry

Plasma 200 ADNI GO, 2 Baseline Plasma Samples, 20 replicates Anticipated Completion Date: 3rd Q 2018
October 2017 Euroimmun New Immunoassays for established AD Biomarkers CSF* 120 ADNI1, GO, 2 CSF  Longitudinal Samples, 20 Pool samples (10+ 10-) Anticipated Completion Date: End of 3rd Q 2018
October 2017 Fujirebio New Immunoassays for established AD Biomarkers CSF* 422 ADNI 1, GO, 2 CSF Longitudinal Samples, 20 Pool Samples (10+ 10-) Anticipated Completion Date: End of 3rd Q 2018
October 2017 MesoScale New Immunoassays for established AD Biomarkers CSF* 250 ADNI 1, GO, 2 CSF Longitudinal Samples, 20 Pool samples (10+ 10-) Date uploaded: 8/8/2018
September 2017 Marc Suarez-Calvert, DZNE, Germany sTREM2 & Progranulin

IA

CSF 1859 ADNI 1, GO, 2 BAELINE + Longtitudinal samples Data uploaded: 2/23/2018
October 2016 Carlos Cruchaga, Washington University School of Medicine sTREM2 & Progranulin

IA

CSF 1859 ADNI 1, GO, 2 BASELINE + Longtitudinal samples Data uploaded: 2/23/2018
August 2017 Henrik Zetterberg, Molndal, Sweden NFL & Tau diagnosis/prognosis

High sensitivity IA

Plasma 3762 ADNI 1, GO, 2 longitudinal aliquot samples

20 replicates

Anticipated Completion Date: End of 3rd Q 2018
May 2017 Jing Zhang,

Harborview Medical Center,

University of Washington School of Medicine

a-Syn, Tau, Ab for AD Diagnosis

IA

Plasma 310 ADNI 1, GO, 2 samples

10 replicates

Anticipated Completion Date:

3rd Q 2018

March 2017 Dan Rader,

Perelman School of Medicine, University of Pennsylvania

Cholesterol efflux Serum 795 ADNI 1 baseline samples

20 replicates

Data uploaded:

6/25/2018

Sept 2015  

Ian Sherriff

Araclon Biotech

 

A?1-42 and A?1-40

IA

Plasma 784 ADNI1, GO, 2

longitudinal aliquot samples

759 PLA aliquots

25 Replicates

Data uploaded: 2/16/2016
  March 2015 Jing Zhang

Harborview Medical Center, University of Washington School of Medicine

 

Total ?-syn

Ser129

Phosphorylated ?-syn

IA

CSF ^372 ADNI1 Baseline CSF aliquots samples

^transferred from Geoff Baird

461 ADNI1, GO, 2

longitudinal aliquot samples

446 CSFs

15 Replicates

Data uploaded: 9/21/2016
9/23/2014 Dr. Kaj Blennow

Clinical Neurochemistry Lab

Tau  Plasma

High sensitivity IA

Plasma 595 ADNI1 aliquot samples

579 Baseline PLA

16 Replicates

Data uploaded: 8/4/2015
07/09/2014 Allan Levey

Emory University School of Medicine

DDE**

Mass spectrometry

Plasma 221 ADNI1 aliquot samples

211 Baseline PLA

10 replicates

Data uploaded: 11/12/2014
05/19/2014 Dr. Kaj Blennow

Clinical Neurochemistry Lab

Cerebrospinal fluid levels

of neurogranin

Neurofilament Light (NFL)

CSF 416 ADNI1 aliquot samples

400 Baseline CSFs

16 Replicates

Data uploaded: 8/20/2014
05/19/2014 Rima Kaddurah-Daouk

Duke University

Metabolic Pathways and Networks in Alzheimer¹s Disease

Mass spectrometry

Serum 833 ADNI1 aliquot samples

813 Baseline SER

20 Replicates

Data uploaded: 8/14/2015
10/28/2013 Courtney  Sutphen

Washington Univ School of Medicine

Lab of Dr. Anne Fagan & David Holtzman

YKL-40 and VILIP-1 in

Longitudinal CSF sample sets

CSF 612 ADNI1, GO, 2

longitudinal aliquot samples

597 CSFs

15 Replicates

Data uploaded: 7/15/2015
Week of 9/24/2012 Lee Honigsberg

Nicholas Lewin-Koh, Angus Nairn, Les Shaw, Dan Spellman, Kristin Wildsmith, co-investigators

 

Steve Hoffmann, PhD

Scientific Program Manager

The FNIH Biomarkers Consortium

CSF proteomic study Caprion using

mrm mass

spectrometry***

CSF 306 ADNI1 aliquot samples

290 Baseline CSFs

16 Replicates

Data uploaded: 4/04/2014
9/12/2012 Dr.Robert  Nagele

UMDNJ

Autoantibody biomarkers for detection and

diagnosis of Alzheimer’s disease

Serum 100 ADNI1 aliquot samples

50 Baseline MCI

50 Baseline NL

Data uploaded: 11/1/2012
5/9/2012 Geoff Baird, Thomas Montine and Elaine Peskind, co-investigators

University of Washington

Analyzing the CSF proteome with an oligonucleotideaptamer array CSF and Plasma 727 ADNI1 aliquot samples

372 Baseline CSFs

and matching 355 PLA

Study cancelled

Samples forwarded to Jing Zhang, PI, for a-SYN studies

1/17/2012 Lee Honigsberg

Nicholas Lewin-Koh, Angus  Nairn,

Les Shaw, Dan Spellman,

Kristin Wildsmith, co-Pis

 

Steve Hoffmann ,PhD, Scientific Program Manager The Biomarkers Consortium Foundation for the National Institutes of Health

Pilot Study

CSF proteomics project Caprion using mrm mass spectrometry*

CSF 25  ADNI1  aliquot samples

20 Baseline CSFs: 10 AD, 10 NL

and 5 aliquots of a CSF pool

Data uploaded: 4/04/2014 with the main mrm MSMS  Proteomic Study
9/26/2011 Mary J Savage, PI

Dan Holder, co- PI

Merck

 

Judy Siuciak, PhD

Scientific Program Manager

The FNIH Biomarkers Consortium

BACE and sAPP in CSF

IA

CSF 402 ADNI1 aliquot samples

382 Baseline CSF

20 Replicates

Data uploaded: 4/24/2012
8/9/2011 William Potter, PI

Eve Pickering, Mitch Kling, Les Shaw, Fred Immerman, co- investigators

 

Judy Siuciak, PhD

Scientific Program Manager

The FNIH Biomarkers Consortium

CSF proteomic

study RBM***

CSF 317 ADNI1 aliquot samples

311 Baseline CSFs

16 Replicates

Data uploaded: 01/03/2012
3/24/2011 Jing Zhang, PI

Harborview Medical Center University of Washington

School of Medicine

CSF Proteomic study CSF 390 ADNI1 aliquot samples

Baseline CSFs:

92 AD, 187 MCI, 111 NC

Data uploaded: 3/11/2013 and

7/12/2013

5/12/2010 1.  Holly Soares (2010-2011)

Pfizer

Eve Pickering & Fred Immerman

Statistical analyses

 

William Potter, Max Kuhn, David Shera, Mats Ferm, Robert A Dean,AdamJ Simon, Frank Swenson, Judy Siuciak, June Kaplow, Madhay Thambisetty, Panayiotis Zagouras,  Walter Koroshetz, Hong Wan, John Q Trojanowski, Leslie M Shaw, co-Investigators

 

David Lee

Scientific Program Manager

 

Judy Siuciak

Scientific Program Manager

The FNIH Biomarkers Consortium

Foundation for the National Institutes of Health

 

2.  William Potter (2011- 2013)

Eve Pickering & Fred Immerman

Statistical analyses

Mitch Kling

Plasma proteomic study Rules Based Medicine (RBM)***

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CSF proteomic study RBM

Plasma

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CSF

1065 ADNI1 aliquot samples Baseline PLA:

394 MCI, 111 AD, 57 NL

Year 1 PLA:

349 MCI, 98 AD, 56 NL

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

317 ADNI1 aliquot samples

311 Baseline CSFs

16 Replicates

Study data uploads:

 

Plasma proteomics RBM study

Nov 19, 2010

 

 

 

 

CSF proteomics RBM study

January 3,2012

3/1/2010 John A. McIntyre

St. Francis Hospital

Redox Reactive Autoantibodies in ADNI subjects

RARC/study phase 2

Serum 90  ADNI1 aliquot samples

Baseline SER:

30 NC, 30 MCI and 30 AD

Data uploaded: 07/21/2011
7/14/2009 John A. McIntyre

St. Francis Hospital

Redox Reactive Autoantibodies in ADNI subjects, RARC/study phase 1 Serum 18 ADNI1 aliquot samples

Baseline SER:

6 NC, 6 MCI and 6 AD

Data uploaded: 11/29/2009
7/13/2009 Lucas Restrepo

UCLA

Immuno signature of Alzheimer’s Disease: using a blood plasma test Plasma 100 ADNI1 aliquot samples

Baseline PLA: 50 AD & 50 NL

Study not completed
12/4/2007 Andy Saykin (2007- 2009)

Dietrich Stephan, co-PI

Indiana University

 

Steven Potkin (2007- 2009)

UC Irvine

Andrew Saykin, co-PI

Indiana University

Whole genome analysis of ADNI1 cohort following DNA extraction(at Cogenics)

 

Genetic association analysis of the ADNI 1 cohort

Whole

blood

807 ADNI1 aliquot samples

ADNI 1 Screening/Visit1 ApoE residual samples

Data uploaded: 3/16/2009

 

Sample type   Total # Aliquots  Shipped
CSF 7699
Plasma 6608
Serum 2252
Whole blood

807

Total 17,366

 

*all CSF aliquot samples were post-AlzBio3 IA with one additional freeze-thaw cycle.

** DDE, a metabolite of pesticide DDT (dichloro-diphenyl-trichloroethane)

 ***PPSB/FNIH Biomarker Consortium-sponsored Proteomic studies

Summary of CSF, Plasma, Serum, Whole Blood Aliquotsshipped to investigators. The table above is a description of aliquots that were sent out to other investigators in the past 11 years (2007 through 2018).  As of 8/02/2018, 7699 CSFaliquots, 6608 plasma aliquots, 2252 serum aliquots, and 807 whole blood samples have been provided to investigators.