Table 1. Summary of CSF, Plasma, Serum, and Whole Blood Aliquots shipped to RARC-approved investigators
| Shipment
Date |
Principal Investigator | Project | Specimen Type | Specimen Number | Data Upload to ADNI/LONI |
|---|---|---|---|---|---|
| Aug, 2021 | Michael Pontecorvo, Eli Lilly & Co | Diagnostic Performance Against the Brain PET Imaging Findings: Evaluation of a Novel Plasma ATN Biomarker | Plasma | 291 plasma from 279 unique participants plus 10 replicate samples | Anticipated Upload 4th Q 2021 |
| June, 2021 | Ivana Delalle, Brown Univ | miRNA | Plasma | 180 plasma including 60 HC, 60 MCI, 60 AD plus 10 replicate plasma samples | Anticipated Upload 4th Q 2021 |
| May, 2021 | Carlos Cruchaga, Wash Univ | CSF-derived miRNA’s as AD biomarkers in Plasma | Plasma | 367 Plasma
10 replicates
|
Anticipated Upload 3rd Q 2021 |
| November, 2020 | Julie Saugstad, OHSU | CSF-derived miRNA’s as AD biomarkers in Plasma | Plasma & CSF | 80 Plasma, 80 matched CSF for HC 80 Plasma, 80 matched CSF for AD 5 CSF replicates, 5 plasma replicates |
Anticipated Upload 3rd Q 2021 |
| April, 2021 | Allan Levey, Emory University | CSF proteome | CSF | 719 CSFs matched to Rima K-D serum 10 replicates |
Anticipated Upload 4th Q 2021 |
| 3rd Q 2020 | FNIH BC plasma Aβ study group | Round robin for plasma Aβ42/40; p-tau pilot | Plasma | 130 ADNI GO/2 to each of 6 participating labs |
2nd Q 2021 |
| Nov, 2019 | R Bateman, Wash U, LC/MSMS | Aβ42/Aβ40 in CSF & plasma | CSF/Plasma | 638 plasma 487 CSF |
Anticipated completion: 3rd Q 2021 |
| August, 2019 | Kina Hoglund, Kaj Blennow Molndal, Sweden {ELISA, Simoa} |
Novel markers of tau pathology & synaptic loss (TAU368 & GAP-43) |
CSF | 1,286 ADNIGO/2 Baseline + longitudinal samples, 20 replicates |
Date Uploaded: 6/08/2021 |
| July 2018 | Robert Nagele, UMDNJ
(Autoantibody Array) |
Autoantibodies for AD detection | Serum | 406 ADNI1/GO/2 Baseline + Longitudinal Samples, 10 replicates | Date Uploaded: 12/18/2018 |
| March 2018 | William Hu, Emory University Center for Neurodegenerative Diseases | CSF Cytokines/Chemokines
IA |
CSF | 388 ADNIGO/2 Baseline + longitudinal Samples, 10 replicates | Date Uploaded: 1/04/2019 |
| January 2018 | FNIH BC/Caprion Proteome Inc., Washington DC/Montreal, Quebec, Canada {LC/MSMS} | CMGA, NPTX2, VGF, CG2, FABP
mrm/mass spectrometry |
CSF | 730 ADNI1, GO, 2 CSF Longitudinal Samples, 20 replicates | Date uploaded: April, 2019 |
| November 2017 | Randall Bateman, Washington University School of Medicine | Ab42/Ab40 in plasma of FBP+ / FBP-
mrm/mass spectrometry |
Plasma | 200 ADNI GO, 2 Baseline Plasma Samples, 20 replicates | Date uploaded: June, 2019 |
| 10/2017 for EI/FRB/MSD 9/2018 for S/S |
Euroimmune, Fujirebio MSD, Saladax/Siemens |
New immunoassays for established AD biomarkers | Residual CSF | EI: 120 + 20 pool samples FRB: 422 + 20 pool samples MSD: 250 + 20 pool samples S/S: 373 + 20 pool samples |
MSD 8/9/18 Euroimmune 4/19/19 FRB 3rd Q 2019 |
| September 2017 | Carlos Cruchaga, Wash U, and Marc Suarez-Calvert, DZNE, Germany {Immunoassays} |
sTREM2 & Progranulin | CSF | 1859 ADNI 1, GO, 2 BAELINE + Longtitudinal samples | Data uploaded: 2/23/2018 |
| August 2017 | Henrik Zetterberg, Molndal, Sweden {Simoa} |
NFL & Tau diagnosis/prognosis
p-tau181 added |
Plasma | 3762 ADNI 1, GO, 2 longitudinal aliquot samples
20 replicates |
NfL : 10/13/2018; p-tau181 uploaded 6/2020 |
| May 2017 | Jing Zhang,
Harborview Medical Center, University of Washington School of Medicine |
a-Syn, Tau, Ab for AD Diagnosis | Plasma | 310 ADNI 1, GO, 2 samples
10 replicates |
Data uploaded: 8/31/2020 |
| March 2017 | Dan Rader,
Perelman School of Medicine, University of Pennsylvania |
Cholesterol efflux | Serum | 795 ADNI 1 baseline samples
20 replicates |
Data uploaded: 2nd Q 2018 |
| July 2016 | Rima Kaddoura-Daouk Duke University {multiple LC/MSMS} |
Metabolic networks | Serum | 905* ADNIGO/2 BL samples 15 triplicates Each sub-aliquotted: 6,335 total |
Data uploaded:
Throughout 2017 |
| 9/15/2015 | Ian Sherriff, PI
Araclon Biotech |
Aβ1-42 and Aβ1-40
IA |
Plasma | 784 ADNI1, GO, 2
longitudinal aliquot samples 759 PLA aliquots 25 Replicates |
Data uploaded: 2/16/2016 |
| 3/17/2015 | Jing Zhang, PI
Harborview Medical Center, University of Washington School of Medicine |
Total α-syn
Ser129 Phosphorylated α-syn IA |
CSF | *372 ADNI1 Baseline CSF aliquots samples
*transferred from Geoff Baird 461 ADNI1, GO, 2 longitudinal aliquot samples 446 CSFs 15 Replicates |
Data uploaded: 9/21/2016 |
| 9/23/2014 | Dr. Kaj Blennow, PI
Clinical Neurochemistry Lab |
Tau Plasma
High sensitivity IA |
Plasma | 595 ADNI1 aliquot samples
579 Baseline PLA 16 Replicates |
Data uploaded: 8/4/2015 |
| 07/09/2014 | Allan Levey, PI
Emory University School of Medicine |
DDE**
Mass spectrometry |
Plasma | 221 ADNI1 aliquot samples
211 Baseline PLA 10 replicates |
Data uploaded: 11/12/2014 |
| 05/19/2014 | Dr. Kaj Blennow, PI
Clinical Neurochemistry Lab |
Cerebrospinal fluid levels
of neurogranin Neurofilament Light (NFL) |
CSF | 416 ADNI1 aliquot samples
400 Baseline CSFs 16 Replicates |
Data uploaded: 8/20/2014 |
| 05/19/2014 | Rima Kaddurah-Daouk, PI
Duke University |
Metabolic Pathways and Networks in Alzheimer’s Disease
Mass spectrometry |
Serum | 833 ADNI1 aliquot samples
813 Baseline SER 20 Replicates |
Data uploaded: 8/14/2015 |
| 10/28/2013 | Courtney Sutphen, PI
Washington Univ School of Medicine Lab of Dr. Anne Fagan & David Holtzman |
YKL-40 and VILIP-1 in
Longitudinal CSF sample sets |
CSF | 612 ADNI1, GO, 2
longitudinal aliquot samples 597 CSFs 15 Replicates |
Data uploaded: 7/15/2015 |
| Week of 9/24/2012 | Lee Honigsberg, PI
Nicholas Lewin-Koh, Angus Nairn, Les Shaw, Dan Spellman, Kristin Wildsmith, co-investigators Steve Hoffmann, PhD Scientific Program Manager The FNIH Biomarkers Consortium |
CSF proteomic study Caprion using
mrm mass spectrometry |
CSF | 306 ADNI1 aliquot samples
290 Baseline CSFs 16 Replicates |
Data uploaded: 4/04/2014 |
| 9/12/2012 | Dr.Robert Nagele, PI
UMDNJ |
Autoantibody biomarkers for detection and
diagnosis of Alzheimer’s disease |
Serum | 100 ADNI1 aliquot samples
50 Baseline MCI 50 Baseline NL |
Data uploaded: 11/1/2012 |
| 5/9/2012 | Geoff Baird, PI Thomas Montine and Elaine Peskind, co-investigators University of Washington |
Analyzing the CSF proteome with an oligonucleotideaptamer array | CSF and Plasma | 727 ADNI1 aliquot samples
372 Baseline CSFs and matching 355 PLA |
Samples forwarded to Jing Zhang, PI |
| 1/17/2012 | Lee Honigsberg
Nicholas Lewin-Koh, Angus Nairn, Les Shaw, Dan Spellman, Kristin Wildsmith, co-Pis Steve Hoffmann ,PhD, Scientific Program Manager The Biomarkers Consortium Foundation for the National Institutes of Health |
Pilot Study
CSF proteomics project Caprion using mrm mass spectrometry* |
CSF | 25 ADNI1 aliquot samples
20 Baseline CSFs: 10 AD, 10 NL and 5 aliquots of a CSF pool |
Data uploaded: 4/04/2014 with the main mrm MSMS Proteomic Study |
| 9/26/2011 | Mary J Savage, PI
Dan Holder, co- PI Merck Judy Siuciak, PhD Scientific Program Manager The FNIH Biomarkers Consortium |
BACE and sAPP in CSF | CSF | 402 ADNI1 aliquot samples
382 Baseline CSF 20 Replicates |
Data uploaded: 4/24/2012 |
| 8/9/2011 | William Potter, PI
Eve Pickering, Mitch Kling, Les Shaw, Fred Immerman, co- investigators Judy Siuciak, PhD Scientific Program Manager The FNIH Biomarkers Consortium |
CSF proteomic
study RBM* |
CSF | 317 ADNI1 aliquot samples
311 Baseline CSFs 16 Replicates |
Data uploaded: 01/03/2012 |
| 3/24/2011 | Jing Zhang, PI
Harborview Medical Center University of Washington School of Medicine |
ADNI RARC CSF Proteomic study |
CSF | 390 ADNI1 aliquot samples
Baseline CSFs: 92 AD, 187 MCI, 111 NC |
Data uploaded: 3/11/2013 |
| 5/12/2010 | 1. Holly Soares (2010-2011)
Pfizer Eve Pickering & Fred Immerman Statistical analyses William Potter, Max Kuhn, David Shera, Mats Ferm, Robert A Dean,AdamJ Simon, Frank Swenson, Judy Siuciak, June Kaplow, Madhay Thambisetty, Panayiotis Zagouras, Walter Koroshetz, Hong Wan, John Q Trojanowski, Leslie M Shaw, co-Investigators David Lee Scientific Program Manager Judy Siuciak Scientific Program Manager The FNIH Biomarkers Consortium Foundation for the National Institutes of Health 2. William Potter (2011- 2013) Eve Pickering & Fred Immerman Statistical analyses Mitch Kling |
Plasma proteomic study Rules Based Medicine (RBM)*
CSF proteomic study RBM |
Plasma
CSF |
1065 ADNI1 aliquot samples Baseline PLA:
394 MCI, 111 AD, 57 NL Year 1 PLA: 349 MCI, 98 AD, 56 NL 317 ADNI1 aliquot samples 311 Baseline CSFs 16 Replicates |
Study data uploads:
Plasma proteomics RBM study Nov 19, 2010 CSF proteomics RBM study January 3,2012 |
| 3/1/2010 | John A. McIntyre, PI
St. Francis Hospital |
Redox Reactive Autoantibodies in ADNI subjects
RARC/study phase 2 |
Serum | 90 ADNI1 aliquot samples
Baseline SER: 30 NC, 30 MCI and 30 AD |
Data uploaded: 07/21/2011 |
| 7/14/2009 | John A. McIntyre , PI
St. Francis Hospital |
Redox Reactive Autoantibodies in ADNI subjects, RARC/study phase 1 | Serum | 18 ADNI1 aliquot samples
Baseline SER: 6 NC, 6 MCI and 6 AD |
Data uploaded: 11/29/2009 |
| 7/13/2009 | Lucas Restrepo, PI
UCLA |
Immuno signature of Alzheimer’s Disease: using a blood plasma test | Plasma | 100 ADNI1 aliquot samples
Baseline PLA: 50 AD & 50 NL |
Study not completed |
| 12/4/2007 | Andy Saykin (2007- 2009)
Dietrich Stephan, co-PI Indiana University Steven Potkin (2007- 2009) UC Irvine Andrew Saykin, co-PI Indiana University |
Whole genome analysis of ADNI1 cohort following DNA extraction(at Cogenics)
Genetic association analysis of the ADNI 1 cohort |
Whole
blood |
807 ADNI1 aliquot samples
ADNI 1 Screening/Visit1 ApoE residual samples |
Data uploaded: 3/16/2009 |
*PPSB Proteomic studies
** DDE, a metabolite of pesticide DDT (dichloro-diphenyl-trichloroethane)
Table 2. Overview of CSF, Plasma, Serum, Whole Blood Aliquots shipped
| Sample | # Aliquots Shipped to RARC investigators | |
|---|---|---|
| ADNI1/GO/ | ADNI3: 2016-2021 | |
| CSF | 3618 | 6794 |
| Plasma | 2336 | 6688 |
| Serum | 1041 | 2106 |
| Whole blood |
807 |
_ |
| Total | 7802 | 15,588 |
The table above is a description of aliquots that were sent to other investigators in the past 14 years (2007 through August 2021). A total of 6794 CSF, 6688 plasma, and 2106 serum sample aliquots were shipped to RARC/NIA-approved investigators during the time span of the ADNI3 study.
