There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Karin Meeker |
| Institution: | Saint Louis University |
| Department: | Cognitive Neuroscience |
| Country: | |
| Proposed Analysis: | The purpose of the proposed analysis is to examine the intrinsic fluctuations and anticorrelations between task positive and task negative networks at rest in relation to intraindividual variability (IIV) on neuropsychological assessments. Increased behavioral IIV has been observed in early Alzheimer’s Disease and can be used as a preclinical marker for pathological aging. We will investigate differences between healthy older adults and those with very mild or mild dementia on clinical measures and resting state fMRI. This study will focus on variability across cognitive domains including attention, executive functioning, processing speed, working memory, and verbal memory, extending the work of Anderson and colleagues (2016). In order to carry out these analyses, we request results from all clinical and neuropsychological assessments, as well as the structural and functional MRI data for healthy older adults (CDR=0) and those with early dementia (CDR 0.5-1). |
| Additional Investigators | |
| Investigator's Name: | Jill Waring |
| Proposed Analysis: | The purpose of the proposed analysis is to examine the intrinsic fluctuations and anticorrelations between task positive and task negative networks at rest in relation to intraindividual variability (IIV) on neuropsychological assessments. Increased behavioral IIV has been observed in early Alzheimer’s Disease and can be used as a preclinical marker for pathological aging. We will investigate differences between healthy older adults and those with very mild or mild dementia on clinical measures and resting state fMRI. This study will focus on variability across cognitive domains including attention, executive functioning, processing speed, working memory, and verbal memory, extending the work of Anderson and colleagues (2016). In order to carry out these analyses, we request results from all clinical and neuropsychological assessments, as well as the structural and functional MRI data for healthy older adults (CDR=0) and those with early dementia (CDR 0.5-1). |
