There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Hiroto Kuwabara |
| Institution: | Johns Hopkins University |
| Department: | Radiology |
| Country: | |
| Proposed Analysis: | One of the primary purposes of neuroimaging of tau in AD subjects is to identify tau-positive scans. Published approaches, such as SUVR of 'composite' regions did not discriminate scans of AD subjects from age-matched control subjects (OC) as accurately as one could wish for. We introduced the tau-positive fraction (TPF) which is defined in individual regions as the frequency of voxels that exceed region-specific threshold (= mean + 2.5 of OC) on SUVR images. This variable successfully discriminated AD from OC subjects (specificity: 94% with ‘composite’ TPF; 100% with maximal TPF), compared to ‘composite’ SUVR (82%) in a small cohort (11 AD and 5 OC subjects) using [18F]RO-948 (Wong et al., JNMMI 2018). We would like to test if TPF could improve identification of tau-positive scans with AV-1451 using the ADNI dataset. |
| Additional Investigators |
