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Principal Investigator  
Principal Investigator's Name: Marco Palma
Institution: University of Warwick
Department: MRC Biostatistics Unit
Country:
Proposed Analysis: Improved inference for scalar-on-image regression, with application to brain age estimation. The aim of this research is to build a statistical model that provides estimates of brain age from 3-dimensional structural MR images. The potential differences between the patient's chronological age and her estimated brain age might then be used as an indication of healthy/unhealthy ageing process or neurodegenerative diseases.
Additional Investigators  
Investigator's Name: Thomas Nichols
Proposed Analysis: Quantifying uncertainty in brain-predicted age using scalar-on-image quantile regression. The aim of this research is to produce brain-derived predictions of subject age. The outcome of the statistical model proposed is not only a point prediction, but also a prediction interval which could take into account the uncertainty. These results could potentially inform about the individual ageing process or neurodegenerative diseases.
Investigator's Name: Shahin Tavakoli
Proposed Analysis: Quantifying uncertainty in brain-predicted age using scalar-on-image quantile regression. The aim of this research is to produce brain-derived predictions of subject age. The outcome of the statistical model proposed is not only a point prediction, but also a prediction interval which could take into account the uncertainty. These results could potentially inform about the individual ageing process or neurodegenerative diseases.
Investigator's Name: Julia Brettschneider
Proposed Analysis: Quantifying uncertainty in brain-predicted age using scalar-on-image quantile regression. The aim of this research is to produce brain-derived predictions of subject age. The outcome of the statistical model proposed is not only a point prediction, but also a prediction interval which could take into account the uncertainty. These results could potentially inform about the individual ageing process or neurodegenerative diseases.