There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Jia Liu |
| Institution: | Capital Medical University |
| Department: | School of Public Health |
| Country: | |
| Proposed Analysis: | Observational studies have shown a relationship between higher serum uric acid levels and increased risk of dementia. On the other hand, serum uric acid may be neuroprotective in Alzheimer or Parkinson dementia owning to its antioxidant properties. However, causality has not been confirmed and there is considerable potential for confounding. The Mendelian randomization (MR) approach can overcome some of the limitations of observational studies such as confounding or reverse causation to make causal inferences. MR uses single‐nucleotide polymorphisms as instruments to study the effect of varying an exposure on risk of a particular outcome. In this study, we plan to perform MR analyses investigating the relationship between genetically determined serum uric acid levels and cognitive performance and Alzheimer disease. |
| Additional Investigators |
