There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Giorgos Papanastasiou |
| Institution: | University of Edinburgh |
| Department: | Edinburgh Imaging-QMRI |
| Country: | |
| Proposed Analysis: | Dear ADNI, I am a computational imaging scientist and one of my main research interests is to develop pharmacokinetic modelling techniques for multi-modal (MRI, PET, CT) imaging data (see Uni profile in: https://www.research.ed.ac.uk/portal/en/persons/giorgos-papanastasiou(d17f9113-2c82-49b0-a1b5-7ea831510793).html and publications in https://www.researchgate.net/profile/Giorgos_Papanastasiou). At the moment, I develop a new model-based technique to estimate arterial input functions that are needed for pharmacokinetic-compartmental modelling of dynamic PET data. To validate my model-based input functions, I need to assess it in experimental PET data, ideally using metabolite-corrected input functions and target and reference tissue time-activity curves. For this reason, I am very interested to access your ADNI2 Florbetapir PET data, which will be used as ground truths for my model investigations and developments. In my next steps, I aim to assess further this technique in our PET-MR Flutemetamol data (my technique can be adapted for other tracers such as Flutemetamol), but as we don't yet have arterial sampling in our centre, an experimental validation using your data would be a very important stepping stone (which will also be described in publications of course). With best wishes and thank you for considering my application. Dr Giorgos Papanastasiou Computational Imaging and Data Scientist MRC-funded Research Associate University of Edinburgh |
| Additional Investigators |
