There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Miles Berger |
| Institution: | Duke University Medical Center |
| Department: | Anesthesiology Dept |
| Country: | |
| Proposed Analysis: | I am interested in examining proteomic biomarker data in the CSF of patients with AD vs MCI vs normal controls, and as a function of AD risk allele carrier status (ie in TREM2, ApoE, CR1, etc). We are planning on adding an amendment to our IRB protocol (number listed below) to also cover allowing us to review ADNI data, in addition to the prospective data we are obtaining in our patient cohort under this protocol. This will allow us to compare protein changes in the CSF seen before vs after surgery in older adults to protein changes in the CSF seen in MCI and AD. |
| Additional Investigators | |
| Investigator's Name: | Mary Cooter |
| Proposed Analysis: | CSF protein analysis as mentioned in the main submission form. |
| Investigator's Name: | Yi-Ju Li |
| Proposed Analysis: | CSF protein analysis as mentioned in the main submission form. |
| Investigator's Name: | Jeff Browndyke |
| Proposed Analysis: | CSF protein analysis as mentioned in the main submission form, as well as analysis of the relationship between CSF protein changes and fMRI changes seen in patients with MCI and or AD, and as a function of AD risk allele carrier status |
| Investigator's Name: | David Corcoran |
| Proposed Analysis: | Together with Dr Berger, we are interested in examining proteomic biomarker data in the CSF of patients with AD vs MCI vs normal controls, and as a function of AD risk allele carrier status (ie in TREM2, ApoE4, CR1, etc). |
| Investigator's Name: | Jennifer Modliszewski |
| Proposed Analysis: | Together with Drs Berger and Corcoran, Dr Modliszewski will be analyzing targeted proteomic data from the ADNI study for proteomic signatures of specific AD risk alleles (APOE4, TREM2, etc). |
| Investigator's Name: | Melody Reese |
| Proposed Analysis: | Dr Reese will be assisting with our work on the mechanisms by which APOE4 contributes to AD risk, including CSF proteomic correlates of APOE4 genotype. |
