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Principal Investigator  
Principal Investigator's Name: Katelyn McKenzie
Institution: University of Kansas Medical Center
Department: Biostatistics & Data Science
Country:
Proposed Analysis: The objectives of this proposal are to advance statistical methodologies concerning agreement studies, which is the current methodologic tool for evaluating diagnostic tests and biomarkers. We will develop a novel statistical approach to assess factors associated with Alzheimer’s disease imaging status. Importantly, this statistical approach can be generalized for use to the greater medical community. Specifically, we will leverage brain images and subject characterizations from ADNI and recruit providers to assess these imaging biomarkers. By using this novel statistical methodology, we will identify features that drive agreement in the interpretation of brain images from ADNI as biomarkers for pre-clinical Alzheimer’s disease.
Additional Investigators  
Investigator's Name: Jonathan Mahnken
Proposed Analysis: The objectives of this proposal are to advance statistical methodologies concerning agreement studies, the current methodologic tool for evaluating diagnostic tests and biomarkers. We will develop a novel statistical approach to assess factors associated with Alzheimer’s disease imaging status. Importantly, this statistical approach will be generalizable to the greater medical community. Specifically, we will leverage brain images and subject characterizations from ADNI and recruit providers to assess these imaging biomarkers. In doing so, we will identify features that drive agreement in the interpretation of these images as biomarkers for pre-clinical Alzheimer’s disease.
Investigator's Name: Jeffrey Burns
Proposed Analysis: The objectives of this proposal are to advance statistical methodologies concerning agreement studies, the current methodologic tool for evaluating diagnostic tests and biomarkers. We will develop a novel statistical approach to assess factors associated with Alzheimer’s disease imaging status. Importantly, this statistical approach will be generalizable to the greater medical community. Specifically, we will leverage brain images and subject characterizations from ADNI and recruit providers to assess these imaging biomarkers. In doing so, we will identify features that drive agreement in the interpretation of these images as biomarkers for pre-clinical Alzheimer’s disease.