There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
Principal Investigator | |
Principal Investigator's Name: | Busra Gok |
Institution: | Boston University |
Department: | Biology |
Country: | |
Proposed Analysis: | Specific Aim: To identify molecular markers for Alzheimer’s Disease (AD) by performing massively parallel single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from AD patients, Asymptomatic AD (AsymAD) patients and healthy controls. Our goal is to find new molecular markers and novel therapeutic targets in the peripheral blood immune system of Alzheimer’s Disease patients and find early markers by profiling AsymAD patient PBMCs. We will utilize a cutting edge technology, massively-parallel single cell RNA-seq, where thousands of single cells are simultaneously analyzed in emulsion droplets. We will obtain single cell resolution mRNA expression profiles for each of the immune cell subtypes in the peripheral blood samples from AD patients and matching controls. Bioinformatic analysis will be performed to identify novel molecular markers and potential therapeutic targets in AD. |
Additional Investigators | |
Investigator's Name: | Christine Cheng |
Proposed Analysis: | Specific Aim: To identify molecular markers for Alzheimer’s Disease (AD) by performing massively parallel single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from AD patients, Asymptomatic AD (AsymAD) patients and healthy controls. Our goal is to find new molecular markers and novel therapeutic targets in the peripheral blood immune system of Alzheimer’s Disease patients and find early markers by profiling AsymAD patient PBMCs. We will utilize a cutting edge technology, massively-parallel single cell RNA-seq, where thousands of single cells are simultaneously analyzed in emulsion droplets. We will obtain single cell resolution mRNA expression profiles for each of the immune cell subtypes in the peripheral blood samples from AD patients and matching controls. Bioinformatic analysis will be performed to identify novel molecular markers and potential therapeutic targets in AD. |