There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | WU ZHIWEI |
| Institution: | Soochow University |
| Department: | First Affiliated Hospital of Soochow University |
| Country: | |
| Proposed Analysis: | Phosphatidylinositolbinding clathrin assembly protein (PICALM) was a sensitive gene which was recently discovered genetic risk factors for late-onset Alzheimer’s disease (LOAD). Some studies proved that PICALM gene might help to relieve the AD occurrence rate, however, the mechanism was still an enigma. Researchers demonstrated that PICALM gene was pertaining to influence some neuroimaging traits which would provide important confirmation of a role for the genetic variants and the pilot study showed there were brain functional networks changes in LOAD patients. Therefore, we put forward a hypothesis that PICALM gene would influence biological processes underlying development of AD, might by some neuroimaging traits changes, containing brain structure measurements, functional circuit, as well as brain metabolism changes. This program focuses on the changes of brain structure, brain functional networks and brain amyloid metabolism in LOAD patients and the correlations between these chang |
| Additional Investigators | |
| Investigator's Name: | 宋 子阳 |
| Proposed Analysis: | Phosphatidylinositolbinding clathrin assembly protein (PICALM) was a sensitive gene which was recently discovered genetic risk factors for late-onset Alzheimer’s disease (LOAD). Some studies proved that PICALM gene might help to relieve the AD occurrence rate, however, the mechanism was still an enigma. Researchers demonstrated that PICALM gene was pertaining to influence some neuroimaging traits which would provide important confirmation of a role for the genetic variants and the pilot study showed there were brain functional networks changes in LOAD patients. Therefore, we put forward a hypothesis that PICALM gene would influence biological processes underlying development of AD, might by some neuroimaging traits changes, containing brain structure measurements, functional circuit, as well as brain metabolism changes. This program focuses on the changes of brain structure, brain functional networks and brain amyloid metabolism in LOAD patients and the correlations between these chang |
