There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Kelly Peres |
| Institution: | AstraZeneca |
| Department: | Department of AI and Analytics |
| Country: | |
| Proposed Analysis: | In practice, the brain is best represented by multiple networks arising from different imaging modalities. I intend on using fMRI, MRI and DTI data to create morphometric similarity maps between AD patient and healthy controls (to assess atrophy in each region). I will use graph neural networks for the fMRI MRI and DTI data to create ROI importance maps. I will use a multimodal GNN (MM-GNN) model that incorporates multiple types of neuroimaging-based brain connectivity. The resulting ROI importance maps have the potential to shed light on the biological mechanisms of Alzheimer's. partial least squares regression could be used to associate multi-modal ROI importance scores with spatial transcriptomic data to assess which genes are most strongly expressed in these regions, and therefore which biological pathways might be implicated. |
| Additional Investigators | |
| Investigator's Name: | Jay Nanavati |
| Proposed Analysis: | Using fMRI/sMRI and DTI data as part of a multi-modal GNN for diagnosis classification. |
