Ongoing Investigations

ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator  
Principal Investigator's Name: Valerie Anderson
Institution: Oregon Health & Science University
Department: Advanced Imaging Research Center
Country:
Proposed Analysis: We propose to compare the effect of blood-CSF barrier disruption, as measured by 7T DCE-MRI, on amyloid deposition in the cortex of patients with mild Alzheimer's disease and cognitively normal elderly controls. Subjects will be ADNI2 participants enrolled at the Layton Aging and Alzheimer's Disease Center (J. Kaye, PI) for whom dynamic 18F-AV-45 PET data are available. These subjects will undergo a single DCE-MRI scan at the OHSU Advanced Imaging Research Center at least 3 months prior to any scheduled ADNI2 visit. We anticipate requesting 18F-AV-45 PET scans from a total of 25-30 ADNI2 participants. If approved, we will submit a modification of our active 7T DCE-MRI IRB protocol ("Quantitative Measurement of Cerebrovascular Permeability in Early Dementia") to provide protection of human subjects.
Additional Investigators