There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | James McVittie |
| Institution: | University of Regina |
| Department: | Mathematics and Statistics |
| Country: | |
| Proposed Analysis: | The goals of this research project are (i) to develop statistical procedures which account for potential measurement error in the observed onset dates of diseases with insidious onset processes, such as Alzheimer's disease or vascular dementia, (ii) to develop statistical procedures that are applicable to data collected from a prevalent cohort study with follow-up and (iii) to develop methods for combining different types of survival data. The goal of this work is intended to not only fill gaps in the statistical literature with respect to these research questions but to provide practitioners and health researchers with the tools to analyze these complicated types of datasets. By accounting for measurement error in the onset dates, developing techniques for prevalent cohort data and having the survival analysis tools to combine datasets together, we can develop statistical procedures which yield more accurate and precise estimates of the survival distribution for these types of conditions and study designs. These theoretical approaches will be applied to the ADNI data set with respect to the survival times of subjects measured from reported onset until death in conjunction with the Alzheimer's disease and vascular dementia survival data from the Canadian Study of Health and Aging to better understand the factors affecting survival with these neurological conditions. By accounting for measurement error in the observed onset dates and being able to leverage data from multiple sources, we can more accurately model the underlying survival time with these types of diseases and understand how the reported onset dates of neurological conditions relate to the true underlying onset dates. |
| Additional Investigators |
