There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Patrycja Dzianok |
| Institution: | Nencki Institute of Experimental Biology PAS |
| Department: | Laboratory of Emotions Neurobiology |
| Country: | |
| Proposed Analysis: | I have received a grant in 2018/2019 from Polish National Center (2018/31/N/HS6/03551) named “Executive attention, genetic risk of Alzheimer's disease and cingulate cortex: an EEG and fMRI study”. In this grant, we are studying presymptomatic, healthy individuals with increased genetic risk of late-onset AD (APOE/PICALM) and trying to answer the question of how the risk genes may be related to brain activity and health in general and whether the direction of those presumed changes is similar to that detected in Alzheimer’s disease patients. We have for example found differences in blood granulocytes profiles (especially in eosinophils) between risk-carriers and non-carriers, that presumably uncover early changes in the immune system related to chosen risk-genes (the manuscript is in preparation). We have also found several other differences between risk-carriers and non-carriers in regards to MRI/EEG and behavioral tests. We would like to have an opportunity to check the same hypotheses among MCI/AD ADNI patients with use of available ADNI data e.g. APOE carriers vs. non carriers in regards to granulocytes profiles. |
| Additional Investigators |
