There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Sinthujah Vigneswaran |
| Institution: | Amsterdam UMC - location VUmc |
| Department: | The Alzheimer Center Amsterdam |
| Country: | |
| Proposed Analysis: | There is little data regarding Alzheimer’s disease (AD) related gene expression in peripheral blood given that systemic factors such as inflammation, oxidative stress, and immune function are posited to play important roles in AD risk or progression. Therefore, we hypothesize that expression of genes in peripheral blood can be associated with the biological and clinical relevance in the context of AD. To this end we have formulated 3 objectives, to test the hypothesis that dysregulated genes in AD modifies the effect of amyloid-beta (and perhaps tau) on cognitive decline, to test the hypothesis that dysregulated genes are associated with the inflammatory response in AD and to investigate if genetic (APOE genotype), demographic (age, sex) and other risk factors (comorbidities such as diabetes, obesity and frailty) are associated with dysregulated genes. |
| Additional Investigators |
