There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | WEN luo |
| Institution: | wuhan university |
| Department: | NEUROLOGY |
| Country: | |
| Proposed Analysis: | MELAS syndrome is a rare mitochondrial genetic disorder caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA. Stroke-like episodes (SLES), epileptic seizures, mental and cognitive impairments, hyperlactatemia, weakness, and muscle intolerance are the predominant clinical manifestations. Because of the variety of symptoms, cerebral infarction, viral encephalitis, and other brain diseases are frequently misdiagnosed as the condition. It is noteworthy that MELAS is often accompanied by other systemic manifestations such as short stature, hypothyroidism, DM, dilated or hypertrophic cardiomyopathy and heart block, kidney disease, and retinal and optic neuropathy. |
| Additional Investigators | |
| Investigator's Name: | qingrong ouyang |
| Proposed Analysis: | MELAS syndrome is a rare mitochondrial genetic disorder caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA. Stroke-like episodes (SLES), epileptic seizures, mental and cognitive impairments, hyperlactatemia, weakness, and muscle intolerance are the predominant clinical manifestations. Because of the variety of symptoms, cerebral infarction, viral encephalitis, and other brain diseases are frequently misdiagnosed as the condition. It is noteworthy that MELAS is often accompanied by other systemic manifestations such as short stature, hypothyroidism, DM, dilated or hypertrophic cardiomyopathy and heart block, kidney disease, and retinal and optic neuropathy. |
