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Principal Investigator  
Principal Investigator's Name: Lars Frings
Institution: University of Freiburg
Department: Department of Nuclear Medicine
Country:
Proposed Analysis: The aim of the data analysis is to assess the co-variation between Aβ load (amyloid PET) and glucose hypometabolism (FDG PET) in the brain. We have recently observed an association of elevated neocortical Aβ with hippocampal hypometabolism in a small group of patients with Alzheimer’s dementia scanned at our site [Frings, L., Spehl, T. S., Weber, W. A., Hull, M. & Meyer, P. T. Amyloid-beta Load Predicts Medial Temporal Lobe Dysfunction in Alzheimer Dementia. J. Nucl. Med. 54, 1909-1914 (2013)]. We would like to do a replication study in a much larger sample, and the ADNI data seem perfect for this.
Additional Investigators