There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Timothy Hohman |
| Institution: | Vanderbilt University School of Medicine |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | This project will identify factors that predict individual resilience to cognitive impairment arising from Alzheimer’s Disease (AD), Traumatic Brain Injury (TBI), or cerebrovascular disease. At autopsy, approximately 30% of cognitively normal individuals have the pathological features of AD or cerebrovascular disease. Yet, to date very little research has focused on the genetic factors that might contribute to such resilience. The focus of the project will be on genetic factors that modify known biomarker effects in confer resilience to neurodegeneration and cognitive impairment, however we will also evaluate cognitive, neural, and demographic factors that may also contribute to this unique phenotype. During my postdoctoral fellowship I began leveraging ADNI data to such an end (http://www.sciencedirect.com/science/article/pii/S1552526014000132) and this project will build on that approach to develop a comprehensive framework of resilience. |
| Additional Investigators | |
| Investigator's Name: | Nico Franzmeir |
| Proposed Analysis: | Dr. Franzmeir will assess the usefulness of polygenic risk scores derived from our primary analyses leveraging a variety of imaging and fluid biomarkers. |
| Investigator's Name: | Shannon Risacher |
| Proposed Analysis: | Dr. Risacher will assist with ADNI MRI curation for the resilience project. |
| Investigator's Name: | David Fardo |
| Proposed Analysis: | Dr. Fardo will assist in joint analysis of endophenotypes with the NACC datasets |
| Investigator's Name: | Rachel Buckley |
| Proposed Analysis: | We will leverage the harmonized PACC scores developed by Dr. Buckley in our resilience definitions to facilitate genomic analysis. |
| Investigator's Name: | Derek Archer |
| Proposed Analysis: | Derek is leading all white matter and diffusion components of the project. |
| Investigator's Name: | Michael Kim |
| Proposed Analysis: | Michael will be assisting with diffusion processing and analysis. |
