There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Michael Marnane |
| Institution: | University of British Columbia Hospital |
| Department: | Neurology Department |
| Country: | |
| Proposed Analysis: | Previous ADNI authors (Carmichael et al.Arch Neurol 2010) have shown that higher baseline white matter hyperintensity (WMH) volume on MRI is associated with greater subsequent 1-year deterioration in cognitive screening tests. We propose to develop these findings by evaluating regional differences in extent and progression of white matter disease (e.g. periventricular versus internal watershed versus subcortical) and how these may relate to cognitive outcomes, specific vascular risk factors, genetic susceptibility markers (eg apoE4 status) and imaging and CSF biomarkers of Alzheimers disease pathology and cerebral amyloid angiopathy. |
| Additional Investigators |
