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Principal Investigator  
Principal Investigator's Name: Christine Fennema-Notestine
Institution: UCSD
Department: Psychiatry and Radiology
Country: United States of America
Proposed Analysis: Using methods developed in collaboration with the Morphometry Biomedical Informatics Research Network (mBIRN), we will use publicly available raw data from the ADNI study to improve image processing techniques and workflows for efficiently handling large numbers of datasets from this elderly population. We will apply these techniques to investigate clinical hypotheses related to differentiating control, MCI, and AD groups and predicting future conversion based on combinations of morphometric, metabolic, neuropsychological, and other available biomarkers. Investigations will include studies of regional volume, cortical thickness, and shape analysis in collaboration with Johns Hopkins co-investigators.
Additional Investigators  
Investigator's Name: Linda K McEvoy
Proposed Analysis: Expertise in classification and discriminability analyses.
Investigator's Name: Anthony Gamst
Proposed Analysis: Image processing and statistical expertise, Dr. Gamst is working with us on the bias correction and intensity normalization work.
Investigator's Name: Randy Notestine
Proposed Analysis: Scientific programming development of bias correction, intensity normalization