There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Colleen Millikin |
| Institution: | University of Manitoba |
| Department: | Clinical Health Psychology, Faculty of Medicine |
| Country: | |
| Proposed Analysis: | My Ph.D. student and I are hoping to use ADNI data to investigate neuropsychological correlates of the development of delusions in participants with MCI and AD. We plan to identify: (1) participants who have delusions (according to NPI-Q) at baseline, and (2) participants who do not have delusions at baseline but do have delusions at one or more follow-up visits. If there are sufficient participants with delusions, we plan to carry out analyses to examine differences between participants with and without delusions. Participants who also have hallucinations will be excluded from the present study. Participants with delusions at baseline will be compared to a matched group of participants with no delusions with respect to performance on baseline neuropsychological testing. Participants who develop delusions will be compared to a matched group that did not have delusions during follow-up. These analyses will examine baseline characteristics of participants who did/did not develop delusions, as well as changes in neuropsychological functioning associated with the development of delusions. We hypothesize that participants who develop delusions will show greater impairment in semantic memory but relatively preserved attention.(These hypotheses are based on a paper I co-authored: Fischer, Ladowsky-Brooks, Millikin, Norris, Hansen, and Rourke, 2006.) We are also interested in neuroimaging changes associated with the development of delusions, but our focus at this time is on the neuropsychological variables. |
| Additional Investigators | |
| Investigator's Name: | Claire Milgrom |
| Proposed Analysis: | Claire Milgrom is a Ph.D. candidate in clinical psychology at Fielding Graduate University. She plans to conduct part of the proposed study for her dissertation research. In our study, we hope to use ADNI data to investigate neuropsychological correlates of the development of delusions in participants with MCI and AD. We plan to identify: (1) participants who have delusions (according to NPI-Q) at baseline, and (2) participants who do not have delusions at baseline but do have delusions at one or more follow-up visits. If there are sufficient participants with delusions, we plan to carry out analyses to examine differences between participants with and without delusions. Participants who also have hallucinations will be excluded from the present study. Participants with delusions at baseline will be compared to a matched group of participants with no delusions with respect to performance on baseline neuropsychological testing. Participants who develop delusions will be compared to a matched group that did not have delusions during follow-up. These analyses will examine baseline characteristics of participants who did/did not develop delusions, as well as changes in neuropsychological functioning associated with the development of delusions. We hypothesize that participants who develop delusions will show greater impairment in semantic memory but relatively preserved attention.(These hypotheses are based on a paper I co-authored: Fischer, Ladowsky-Brooks, Millikin, Norris, Hansen, and Rourke, 2006.) We are also interested in changes in ADL and biomarkers (e.g., MRI, PIB) associated with the development of delusions, but our focus at this time is on the neuropsychological variables. |
| Investigator's Name: | Corinne Fischer |
| Proposed Analysis: | Dr. Fischer is a geriatric psychiatrist based at St. Michael's Hospital and the Li Ka Shing Knowledge Institute in Toronto. She is the co-PI of the neuroimaging analysis project funded by the Canadian Institutes of Health Research (CIHR) Catalyst Grant to investigate changes in MRI and FDG-PET associated with the development of delusions. She is involved in analyses and preparation of manuscripts based on analysis of MRI and FDG-PET data. |
