There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Lianne Reus |
| Institution: | VU medical centre |
| Department: | Alzheimer centre, neurology |
| Country: | |
| Proposed Analysis: | Alzheimer’s disease (AD) is a complex, multifactorial neurodegenerative disorder and the most common cause of dementia. AD has an estimated heritability of 58-79% implying that genetic determinants play a major role in AD. Social withdrawal from friends and family has been identified as a risk factor for several neuropsychiatric disorders, including AD. The proposed study will examine the relationship between AD case-control status and neuropsychological markers. To identify which biological processes are influenced by the genetic predisposition for social withdrawal, the association between polygenic risk scores (PGRS) for social withdrawal and intermediate phenotypes in AD, such as cerbrospinal fluid (CSF) protein levels will be examined. Analyses will be based on data provided by the Alzheimer’s disease Neuroimaging Initiative (ADNI, i.e., target sample). PGRS for social withdrawal will be based on two genome-wide association studies (GWAS); a 7-item social withdrawal measure from the Nijmegen Biomedical Study (NBS) (N = 2988) and a GWAS on social withdrawal in UK Biobank (in preparation). |
| Additional Investigators |
