There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Junhong Yu |
| Institution: | The University of Hong Kong |
| Department: | Department of Psychology |
| Country: | |
| Proposed Analysis: | For every participant identified as amyloid-positive (CSF Aβ1-42 ≤192pg/ml), I will extract across multiple time points: a)Medial temporal lobe (MTL) gray matter volumes b)Fractional anisotropy and mean diffusivity of fornix c)Auditory Verbal Learning Test and d)Logical memory Then, I will carry out the following analyses: 1.Cross-lagged panel analyses of MTL atrophy and fornix diffusion indices; specifically structural equation models (SEM) in which baseline MTL atrophy predicts subsequent fornix diffusion indices, while controlling for baseline fornix diffusion indices and other covariates, as well as the reverse – fornix diffusion indices predicting subsequent MTL atrophy, while controlling for baseline MTL volumes and other covariates 2.Also using SEM, I will examine the additional variance explained by fornix diffusion indices on top of MTL atrophy, and vice-versa, in predicting subsequent memory (latent factor of Auditory Verbal Learning Test and Logical memory), while controlling for baseline memory and other covariates |
| Additional Investigators |
