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Principal Investigator  
Principal Investigator's Name: Honghuang Lin
Institution: Boston University School of Medicine
Department: Department of Medicine
Country:
Proposed Analysis: We have been working on the analysis of Framingham Heart Study. More than two dozen of genetic variants have been identified to associate with MRI image biomarkers and cognitive functions. We would like to validate our findings in ADNI dataset, which contains a comprehensive collection of clinical information as well as genetic/image data. We have also identified multiple gene expression and DNA methylation profiles from Framingham Heart Study. It would be interesting to see how these profiles could be linked with whole genome sequencing data in ADNI.
Additional Investigators  
Investigator's Name: Spencer Low
Proposed Analysis: Spencer will examine the distribution of image biomarkers, and study the association with cognitive status.
Investigator's Name: Biqi Wang
Proposed Analysis: Dr. Wang will build genetic risk score using ADNI data.
Investigator's Name: Huitong Ding
Proposed Analysis: Dr. Ding will build machine learning models from multimodal data to predict cognitive impairment.