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Principal Investigator  
Principal Investigator's Name: Victoria Williams
Institution: MassGeneral Hospital
Department: Neurology
Country:
Proposed Analysis: I would like to access the ADNI multi-plex CSF data as well as any concordant MRI (DTI/ASL) and/or neuropsychological test data. My overall aim is to evaluate the association between CSF VEGF, brain structure (WMSA: white matter signal abnormalities) and cerebral blood flow (CBF as quantified using ASL data). Additional analyses will evaluate whether VEGF mediates the expected association between CBF/WMSA and neuropsychological test performance. The purpose of these analyses is to provide preliminary data for an upcoming NIH career development award in which I hope to expand this line of study in an independent project.
Additional Investigators  
Investigator's Name: Steven Arnold
Proposed Analysis: Dr. Arnold is my postdoctoral mentor and will be overseeing this pilot data project. He is listed as a team member on the Biomarkers Consortium CSF Proteomics Team and has thorough knowledge of CSF biomarker interpretation.