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Principal Investigator  
Principal Investigator's Name: Timo Oberstein
Institution: Friedrich-Alexander University
Department: Department of Psychiatry and Psychotherapy
Country:
Proposed Analysis: In the present study, we would like to identify differences between mild cognitive impairment (MCI) with Tau (Tau+) and amyloid pathology (Ab+) as assessed with CSF biomarkers, MCI Tau+ Ab-, and MCI Tau- and Ab+. Each participant was/will be assessed with the german version of the CERAD neuropsychological battery (CERAD NB+), with MRI of the head including MP RAGE sequence, with CSF diagnostics and with inflammatory plasma biomarkers. Based on the MRI data, a VBM and SBM analysis should be performed and compared with items of the CERAD-NP+ as well as with levels of the other biomarkers. In order to perform a proper sample size calculation, we would like to perform the VBM and SBM Analysis with ADNI data in advance.
Additional Investigators  
Investigator's Name: Haas Anna-Lena
Proposed Analysis: VBM and SBM of MCI possibly due to AD, i.e. Tau+Ab- and Tau-Ab+, and MCI probably due to AD