There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Yanyan Tang |
| Institution: | First Affiliated Hospital of Guangxi Medical University |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | Amyloid-beta (Aβ), a main constituent of senile plaque in Alzheimer disease, is known to be neurotoxic. In our research, the ipsilateral thalamus after cerebral infarction in the middle cerebral artery (MCA) territory in Rats, Aβ accumulated abnormally and aggregated to plaque-like deposits for up to 9 months after MCA occlusion. In two longitudinal diffusion tensor imaging studies, a significant increase in mean diffusivity was noted in the ipsilateral thalamus 1 to 6 months after MCA infarction, whereas fractional anisotropy (FA) remained unchanged. Our purpose is to explore the different mechanisms of brain function connections between dementia patients and patients with cerebral ischemia. |
| Additional Investigators |
