There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Thomas Lancaster |
| Institution: | Cardiff University |
| Department: | School of Medicine |
| Country: | |
| Proposed Analysis: | Title: The association between perfusion MRI cerebral blood flow (CBF) and Alzheimer's disease polygenic risk score. Background: Vascular dysregulation (as defined by perfusion MRI; ASL) are among the first alterations leading to Alzheimer's disease (AD) (Iturria-Medina et al., 2016). However, little is about the aetiology underpinning this process. Genetic risk factors for AD may confer risk by influence brain structure and function via mechanisms that may increases AD susceptibility. Previous work suggests that the combined effects of AD GWAS risk alleles (as estimated by a polygenic risk score) are associated with other MRI biomarkers for AD such as hippocampal volume (Foley et al.,2017). However, we do not know if common genetic risk markers for AD (identified via GWAS) are linked to vascular abnormalities that precede AD. Aim: to quantify the relationship between AD genetic risk and cerebral blood flow. This will help to determine if AD genetic risk factors influence the vascular alterations observed in AD. Hypothesis: AD polygenic risk score will be associated with CBF. We do not have an hypothesis regarding the direction of association or specific cortical regions and will make appropriate statistical correction to control the experiment-wide alpha. |
| Additional Investigators |
