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Principal Investigator  
Principal Investigator's Name: yi zhang
Institution: University of Goettingen
Department: Department of Animal Science
Country:
Proposed Analysis: Machine Learning methods have effectively identified genetic factors for many diseases. Many diseases, including Alzheimer’s disease (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants which together affect phenotype. Based on conventional machine learning methods, we developed a novel graph based semi-supervised learning model to identify pairs of variants whose common occurrence signaled the Alzheimer’s disease phenotype, and to predict the individual genetic risk of Alzheimer’s disease occurrence. We hope it is possible to validate our model by using the datasets from AIBL, ADNI and ADNIDOD.
Additional Investigators