There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Yanshu Li |
| Institution: | Case Western Reserve University |
| Department: | Population Quantitative Health Sciences |
| Country: | |
| Proposed Analysis: | We are a biomedical informatics group at Case Western Reserve University. We propose to investigate the mechanism of Alzheimer's and dementia using ADNI database. We are mainly interested in MRI and PEN image data for research purposes such as drug discovery, disease prediction, and knowledge resourcing. |
| Additional Investigators | |
| Investigator's Name: | Rong Xu |
| Proposed Analysis: | Same as above. University webpage here: http://epbiwww.case.edu/rong-xu-phd/ |
| Investigator's Name: | Qingyong Wang |
| Proposed Analysis: | Type 2 diabetes mellitus (T2DM) is a known risk factor for Alzheimer’s disease (AD). Studies show that metformin, a commonly used antidiabetic agent, is associated with lower incidence of AD and improved cognitive function. However, the underlying mechanisms of metformin improving brain function in AD remain largely unknown. We used Alzheimer’s Disease Neuroimaging Initiative database of 1740 participants (310 AD, 786 mild cognitive impairment, 473 normal) to examine the effect of metformin on brain volume. Several analyses have been performed. First, we used association rule mining of medical history of ADNI participants to investigate the comorbidities of AD, we found 23 comorbidities, among which hyperlipidemia, hypertension and diabetes ranked at top. Second, we used multivariate regression to analyze the association of metformin usage with brain volume in baseline. We found that metformin usage is significantly associated with increased whole brain volume (volume increase: 39 cm3; CI: 0.5 - 77.5, p = 0.047). Furthermore, metformin significantly targets a brain sub-region - rostral middle temporal cortex (volume increase: 2.55 cm3; CI: 0.94 - 4.16; p = 0.0019). We plan to leverage the longitudinal information in ADNI to further investigate the effect of metformin usage on change rate of brain volume. |
