There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Palash Sharma |
| Institution: | University of Kansas Medical Center |
| Department: | Department of Biostatistics & Data Science |
| Country: | |
| Proposed Analysis: | Genetic variants play important role in the mechanism of neurodegenerative Alzheimer’s Disease. Individuals with Alzheimer’s disease are more likely to have an affected mother than an affected father. The mitochondrial DNA (mtDNA) is transmitted exclusively down the maternal line. A few specific mtDNA polymorphisms are overrepresented in Alzheimer’s disease cases as compared to controls and such differences further vary across the haplogroups (sub-populations). We would like to explore the association of the haplogroup-defining mitochondrial SNPs with the Alzheimer’s disease risk and if the association further differs with APOE e4 status. Another goal is to explore how the SNPs assayed at baseline is associated with the disease progression over time as measured by diagnosis based on the change in MMSE and CDR, and other factors. The study will further explore if such association differs further with respect to the APOE e4 status (interaction). The ADNI data will be invaluable resource to investigate those research aims. |
| Additional Investigators | |
| Investigator's Name: | Prabhakar Chalise |
| Proposed Analysis: | Genetic variants play important role in the mechanism of neurodegenerative Alzheimer’s Disease. Individuals with Alzheimer’s disease are more likely to have an affected mother than an affected father. The mitochondrial DNA (mtDNA) is transmitted exclusively down the maternal line. A few specific mtDNA polymorphisms are overrepresented in Alzheimer’s disease cases as compared to controls and such differences further vary across the haplogroups (sub-populations). We would like to explore the association of the haplogroup-defining mitochondrial SNPs with the Alzheimer’s disease risk and if the association further differs with APOE e4 status. Another goal is to explore how the SNPs assayed at baseline is associated with the disease progression over time as measured by diagnosis based on the change in MMSE and CDR, and other factors. The study will further explore if such association differs further with respect to the APOE e4 status (interaction). The ADNI data will be invaluable resource to investigate those research aims. |
