There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Matteo Grudny |
| Institution: | University of Florida |
| Department: | Psychiatry |
| Country: | |
| Proposed Analysis: | The purpose of this protocol is to use existing MRI data sets to determine the relationship between diffusion magnetic resonance imaging metrics and functional connectivity metrics in the normal aged brain. Non-invasive markers of activity and microstructure are possible through the use of state of the art magnetic resonance imaging. These markers are valued because of their potential to monitor altered brain activity and white matter microstructure in mild cognitive impairment and dementia of Alzheimer's type. A major hypothesis to be tested here is that the network science metric called the clustering coefficient is statistically associated with the diffusion MRI metric called the orientation dispersion index. Evidence of this relationship comes from our recent preclinical imaging studies under the One Florida Alzheimer's Disease Research Center (1FL ADRC). The importance of this finding is that this would represent the first reliable set of neuroimaging markers that can relate structural changes to functional changes. Thus, any underlying changes in microstructure (e.g., cells, axons, neurons, extracellular matrix size) associated with dementia and Alzheimer's can be measured and tracked and linked to changes in functional activity (through calculations of the clustering coefficient). Additional objectives of this protocol is to establish the protocol for analyzing diffusion and functional magnetic resonance imaging data sets (1), to carry out quantitative analyses on multiband, multi-shell MRI sequences (not currently available through the 1FL ADRC, but only available in our preclinical rodent imaging studies) (2), to report our findings (3), and to collect data for a National Institutes of Health (NIH) proposal (4). |
| Additional Investigators |
