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Principal Investigator  
Principal Investigator's Name: Matthieu Vanhoutte
Institution: INSERM
Department: Cyceron
Country:
Proposed Analysis: The idea of the study is to investigate the PET and MRI data of the ADNI for developing neuroimaging analysis methods to understand the prognosis of Alzheimer's Disease. We are also acquiring MRI and PET data. We would like to compare the results with the ADNI data for quality control and validation.
Additional Investigators  
Investigator's Name: Brigitte Landeau
Proposed Analysis: Analysis and processing of PET/MRI imaging data as engineer
Investigator's Name: Siya Sherif
Proposed Analysis: Study of the amyloid staging in Azlheimer's disease
Investigator's Name: Salma Bougacha
Proposed Analysis: Analyses on Tau imaging data
Investigator's Name: Elizabeth Kuhn
Proposed Analysis: ADNI was used as an independent cohort of replication. We want to replicate our results on the existing relationships between the subjective cognitive decline (assessed by Ecog from the participant and the study-partner), the cognition (through multiple neuropsychological tests as MMSE, RAVLT, ADAS13) and multimodal neuroimaging data (MRI, FDG-PET and Florbetapir-PET) across the entire clinical continuum of the Alzheimer"s syndrome (Controls, SMD, MCI and Dementia patients). The first study focused on the participant-reported measure of subjective cognitive decline and the second on the study-partner report.
Investigator's Name: Edelweiss Touron
Proposed Analysis: We investigate the brain substrates of subclinical depressive symptoms (assessed by the GDS scale) in cognitively unimpaired elderly using complementary multimodal neuroimaging data (MRI, FDG- and Florbetapir-PET) both in the primary cohort Age-Well (Caen, France) and the replication cohort ADNI